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ML226 treatment resulted in HIF-1 stabilization, upregulation of HIF-1 target genes ( CAIX and VEGF ), and activation of a HIF-1 fluorescent reporter (HRE-GFP ODD ) in HeLa cells, similar to treatment with cell-permeable (DM-2OG

Some patients have very little weight to lose and may only need medication for 1-2 months

There is an urgent need for research protocols to be designed inclusively, with extensive disability awareness training for therapists and appropriate accommodations [144]

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