We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration
The overall improvement in energy levels and metabolism could indirectly contribute to a more stable appetite and reduced cravings
Thymulin also prevented LPS-induced up-regulation of production of several cytokines by spleen lymphocytes and peritoneal macrophages
Wu H T, Mi Z L, Zhang J X, Chen C, Xie S G (2014)
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