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Similarly, some authors observed that metformin users had a lower clinical severity of TC at presentation and a longer disease free survival in metastatic patients (Jang et al., 2015), while other authors did not observe any difference in the risk of developing metastases when compared with non-treated patients (Noh et al., 2019)

Currently, the present understanding of the mechanisms and risk factors underlying the pathogenesis of cardiovascular diseases is limited, although there is increasing interest in the role of trace elements in cardiovascular diseases (5)