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The benefit of GLP-1 RAs appears to be time-dependent: in the LEADER trial, for instance, the absolute risk reduction in all-cause death became more pronounced with longer follow-up, rising from 0.3% at 1 year to 1.4% at 3 years [40]

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This approach ensured that our experimental testing covered a range of chemical scaffolds, providing insights into structure-activity relationships and enhancing the robustness of our validation process

In contrast, eight of the 10 states with the lowest share of patients on GLP-1s are located in the Western U.S., where obesity prevalence tends to be lower

The end of shortage poses meaningful concerns for public health