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In some embodiments, the otic formulation or composition comprises between about 0.001% to about 3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

B vitamins are water soluble so any excess is usually excreted - which means that they need to be regularly taken

Vitamin B12 deficiency is relatively common, particularly among older adults, vegetarians, vegans, and individuals with certain digestive conditions

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