In mature human CD14 + CD16 + monocytes, dopamine (10 6 M5 10 5 M) and SKF38393 (D1-like agonist) increased chemokinesis and transmigration across a model of the bloodbrain barrier (Coley et al., 2015
GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation SUMMARY: Semaglutide & Tirzepatide works primarily by making you sick
Lichtenberg D, Ragimova S, Peled Y, Halpern Z
3) Common pathophysiological mechanisms involving impaired SCFA production, immune-inflammatory activation, and dysregulated neuroactive metabolite metabolism
Lastly, the crystal violet was dissolved in methanol, and the absorbance at 590 nm was measured using a microplate reader