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Overall, these results indicate that SKN-1 is activated in all three sterile mutants and appears to be a key regulator of their lifespan, but is not the factor that accounts for their differential lifespan

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Porter: A new, accurate server for protein secondary structure prediction

GLP-1RAs, particularly liraglutide, can modulate this pathway in disease-specific contexts: In neonatal hypoxic-ischemic brain injury models, liraglutide activates PI3K/Akt signaling, reducing neuronal apoptosis and improving long-term cognitive outcomes (Zeng et al., 2019