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Semaglutide is typically administered through a once-weekly subcutaneous injection, and the dose may be adjusted based on individual response and tolerability

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The mechanism itself is uncertain

(Patil and Mitra 2026) Pigmentation appeared alongside a new medication or dose change - The temporal relationship between starting a drug and developing oral pigmentation is a critical piece of diagnostic information

Wang, W., Pan, D., Liu, Q., Chen, X., & Wang, S