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Hydrolases cleave ester linkages with addition of a molecule of water: The products of this hydrolysis, an acid and an alcohol, are more water-soluble than the parent ester

10.1016/j.neuropharm.2012.09.015 98 SandireddyR.YerraV

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If true, this would suggest that all four PUFs provide target redundancy to ensure robustness to regulating the GSC proliferation vs differentiation balance within the germline (Table 1)