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One well-characterized example involves its role as a crucial structural component of the BRISC (BRCC36 isopeptidase complex), a deubiquitinating enzyme complex that specifically cleaves K63-linked ubiquitin chains

When pro-inflammatory cytokines like TNF- are elevated, they can inhibit the activation of the ERK pathway, leading to reduced BDNF levels and impaired neuroplasticity (De Lamirande and Gagnon 2002)

Cell 126 , 677689 (2006)

Hey further demonstrated that mild visible light can drive diselenide metathesis reactions [61], enabling the construction of cross-linked micelles with improved stability in physiological conditions and tumor-selective degradation

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