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Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines

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Part of the cytoplasmic iron is involved in the normal metabolic activities of the cell, such as the activity of mitoferrin expressed in the mitochondrial inner membrane, which transports iron from the cytoplasm to the mitochondria to participate in the synthesis of heme and ironsulfur clusters (Philpott et al., 2017)

The exact timing varies based on individual factors including blood flow to the injection site, subcutaneous tissue thickness, and metabolic rate