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doi: 10.1016/j.cell.2013.12.016 288 KallioKEHtnenKALehtoMSalomaaVMnnistSPussinenPJ

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Because it is almost entirely metabolized in the liver via CYP2C8, CYP3A4, and CYP2C9, any co-administered substance that stresses or inhibits hepatic enzymes deserves careful evaluation [1]

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Impurities, inconsistent concentrations, or mislabeled vials can all confound results and force investigators to repeat entire projects

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