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Ligand topologies were generated from SMILES strings using AceDRG 64 within the CCP4 suite 65 , with covalent bond geometry restraints manually adjusted in the phenix.refine parameter file

This reduces the risk of hypoglycemia compared to some other diabetes medications, though this risk increases when combined with insulin or sulfonylureas

and patients with a history of myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass grafting, deep vein thrombosis, or pulmonary embolism within 6 months of screening

Patients with pre-existing thyroid conditions should undergo thorough evaluation, including medical history and physical examination, before initiating treatment

More than 9% of patients on glucagon-like peptide-1 receptor agonists who underwent esophagogastroduodenoscopy had retained gastric contents, although the risk for aspiration remained low, according to study results