Clinical results have been presented in conferences, and several studies were conducted regarding its potential benefits
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Consistent with this, we demonstrate that partial inhibition of a single DUB, namely USP7, is sufficient to alter the ubiquitylation of a subset of age-sensitive proteins involved in proteostasis, intracellular trafficking, cytoskeletal organization, and synaptic signaling, yet only weakly recapitulates the global ubiquitylation landscape associated with aging
doi: 10.1016/j.autrev.2020.102743 191 MuSWangWLiuQKeNLiHSunFet al