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Research has shown that combining arginine with glyprolines to form specific peptides can produce intrinsic regulatory effects on pain and aggression

GI side effects during the initial dose escalation phase are expected and typically improve with continued use

The trial design included a core study phase consisting of a four-week screening period, followed by a four-week baseline phase where participants received only a placebo in a single-blind manner, and then a 24-week randomized treatment phase, where participants received either bremelanotide or placebo [1]