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Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity

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Moreover, GI comorbidities such as IBS are frequently observed in CFS/ME, further supporting the hypothesis that gut microbiota imbalances are not merely a consequence of illness but may actively contribute to its pathogenesis (He et al., 2023)

The most typical connective tissue cell that participates in tissue structures is fibroblast