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TCA-CYCLE INTERMEDIATES GENERATE CYTOSOLIC AND MITOCHONDRIAL NADPH Isocitrate and malate are two TCA-cycle metabolites that generate NADPH through mitochondrial and cytosolic forms of isocitrate dehydrogenases (IDH1 and IDH2) and malic enzymes (ME1 and ME3), respectively

Efforts to treat gene haploinsufficiency will necessitate careful consideration of cell type specificity, tissue specificity, and modulating the expression of the correct splicing isoformssomething that will vary across tissues and developmental stages [175]

Trends Endocrinol Metab 20, 436443, 10.1016/j.tem.2009.05.008 (2009)

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