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The next day, the supernatant was decanted into a 15-mL sterile conical centrifuge tube and centrifuged at 400 g for 10 min at 4 C

Despite the possible favorable effects of lithium on gut microbiota composition, the use of this drug has been associated with numerous withdrawals in patients with BD, including nausea, diarrhea, weight gain, fine tremor, hypothyroidism, electrocardiogram anomalies, alterations in renal function and even cognitive side effects [266]

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normal group), the dataset was randomly split into training and testing sets at a 7:3 ratio, ensuring roughly balanced class distributions in both subsets

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