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These findings were corroborated by the study in which genetic depletion of astrocytes from cuprizone-induced demyelination model resulted in impaired microglia recruitment and consequent delay in the clearance of myelin debris and in remyelination (106)

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Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide