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This plateau can be a signal to reassess treatment plans, including the possibility of weaning down the medication

Milder Side Effects : Berberines side effects are typically mild and gastrointestinal

Weight loss stalling can also indicate degraded medication, though other factors like semaglutide plateau and dietary changes need to be ruled out first

Clinical trial data provides objective evidence about efficacy (24.2% weight loss at 48 weeks), safety (88.8% completion rate), side effects (peak at weeks 6-8, resolve by week 12 for most), and discontinuation outcomes (70-80% regain over 12-18 months, not immediately)

If phentermine provided temporary results followed by complete regain, the switch to a GLP-1 approach often delivers different outcomes because the mechanism is fundamentally different