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Ghrelin (the hunger hormone) increases, leptin (the satiety hormone) decreases, and insulin sensitivity worsens

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Current law blocks Medicare weight-loss drug coverage Policy changes expected mid-2026 Medicaid coverage remains state-dependent What This Means for You Coverage is stable: Wegovy's preferred status on Aetna expected to continue Focus on PA requirements: Meeting criteria is key to approval Cardiovascular benefit: Wegovy's heart health approval (March 2024) strengthens your case During open enrollment: Confirm no changes to your specific plan's requirements CALL YOUR INSURANCE Verify Your Specific Coverage Verify Your Specific Coverage Even though it takes a little more time, we recommend calling so you can speak with a person who may have more information than the online directory or PDF formulary listing

In the diabetes study, GI adverse effects were reported by 13-50% in the retatrutide group, 35% in the dulaglutide group, and 13% in the placebo group [4]