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Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects

They can affect the survival, proliferation, metastasis, recurrence, drug resistance, and other functions of tumor cells through altering the function, activity, subcellular localization, protein-protein interactions, protein stability, other modification levels of non-histone proteins, and modifying histones to change gene expression, chromatin accessibility, transcriptional activity, all of which are closely related to the initiation and progression of tumors

Brandt, L., et al

20 Heavy metals such as mercury, arsenic, lead, and cadmium can also interfere with healthy brain function

J Immunol 173:28596, PMID: 15210786 DAlessio M, De Nicola M, Coppola S, Gualandi G, Pugliese L, Cerella C, Cristofanon S, Civitareale P, Ciriolo MR, Bergamaschi A, Magrini A, Ghibelli L (2005) Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis