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The same mechanism that extends the replicative life of healthy cells also supports the proliferation of cancer cells, which are defined by their ability to bypass normal telomere-based growth limits

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To understand the underlying mechanisms, inhibitors targeting the Notch pathway (DAPT) and NF-B pathway (BMS) were also applied to HUVEC and murine CLI models

Ozempic commonly causes gastrointestinal side effects, such as nausea, vomiting, constipation, and diarrhea, while phentermine can lead to dry mouth, insomnia, and jitteriness