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In a study that evaluated the efficacy of Bupi Shugan Decoction combined with sound therapy in 64 patients with chronic tinnitus attributed to liver depression and spleen deficiency who also presented with anxiety symptoms, compared with sound therapy alone, the combination treatment significantly improved THI, VAS, Self-Rating Anxiety Scale (SAS), and TCM syndrome scores, indicating symptomatic relief, anxiety reduction, and improved quality of life

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Ally BA, McKeever JD, Waring JD, Budson AE

In the latest Cochrane review of 12 placebo-controlled trials, supplementation with folic acid, vitamin B 6 , and vitamin B 12 either alone or in combination did not affect the risk for myocardial infarction and was associated with only a very small reduction in risk for stroke (RR, 0.90