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We also know that low levels of NAD+ have some quite harmful effects on our bodies, such as: Suffocating our bodies cells Increasing risk of sunburns and skin cancer Associated with fatigue Quickens Aging Worsens weight gain and metabolic syndrome Decreases Cellular Antioxidants May worsen Cardiovascular Diseases May contribute to Multiple Sclerosis Can Impair Brain Function Harms Immune Balance/Function Increases Inflammation Decreases metabolism along with Thyroid Hormones Many of the harmful symptoms of low NAD+ can be likened to the symptoms of aging itself

Generalizing from KEGG to all available databases for ontologic corroboration produced similar results, as depicted in Figure 3B

Valentino, M A et al

These were treatment-resistant cases

Warm regards, Rajsree Nambudripad, MD