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Researchers have also observed the increased expression of pro-inflammatory cytokines such as IL-6 and IL-8 in the tumor microenvironment [50]

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it can centrally inhibit bone formation by binding to leptin receptors in the hypothalamus or locally promote bone formation and inhibit bone resorption by binding to receptors expressed on the surface of osteoblasts [100]

Stop taking Saxenda immediately Sudden, severe joint pain with fever (temperature above 38C), which could indicate septic arthritis requiring emergency treatment Contact your GP promptly (same day) if you develop: First episode of sudden onset severe joint pain, redness, and swelling , to exclude septic arthritis and start appropriate treatment Recurrent gout attacks if you have a previous history Severe right-upper abdominal pain, fever or yellowing of skin/eyes , which could indicate gallbladder problems (a known risk with weight loss and GLP-1 medications) [1] Persistent nausea, vomiting, or diarrhoea that prevents adequate food or fluid intake Signs of dehydration , including dark urine, dizziness, or reduced urination Contact your GP within a few days if you experience: Symptoms of thyroid issues , such as a lump in the neck, persistent hoarseness, or difficulty swallowing Unexplained weight loss plateau or concerns about treatment effectiveness Routine follow-up should include: Regular monitoring appointments as recommended by your prescriber (typically every 3-6 months) Discussion of any new symptoms or concerns, however minor they may seem Review of weight loss progress and whether Saxenda remains appropriate Assessment of cardiovascular risk factors and overall metabolic health Medication review to identify potential drug interactions Remember that most patients tolerate Saxenda well , and serious side effects are uncommon