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The question is whether topical delivery is enough

Many age-related changes in circadian rhythms and sleep architecture, such as reduced rhythm amplitude, phase advance, and altered sleep consolidation, may reflect adaptive remodeling of the circadianhomeostatic system rather than intrinsic dysfunction (Scullin and Bliwise, 2015)

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Jumping to higher doses too quickly is one of the biggest reasons people experience strong side effects

There are two versions of this compound often found in supplements: the less potent version is simply called Alpha Lipoic Acid, while a version known as R Alpha Lipoic Acid is approximately twice the strength because it only contains the R isomer as opposed to a 50/50 ratio of the active R form and the relatively inactive S form