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Additionally, the Neh2 structural domain contains lysine residues, which are substrates for ubiquitination and are involved in the degradation of the Nrf2 protein [16]

In line with FDA guidance that clinicians monitor for new or worsening depression, suicidal thoughts, or unusual changes in mood during GLP-1 RA treatment [46], brief psychological screening should be incorporated at baseline and repeated at intervals during treatment at weeks 6, 12, and 24, and then at least every six months