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For the latter, it is not only known that PAR2 signaling induces IR in adipocytes (125), but PAR2 might also be a substantial contributor to inflammatory and metabolic dysfunction (126)

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Particular emphasis will be placed on exploring the potential mechanisms and clinical applicability of L-citrulline in preserving human sperm function, with the goal of advancing its translation into evidence-based strategies for male reproductive health

Consistent with this observation, the process of T cell activation is accompanied by the upregulation of both SLC1A5 and SLC38A1, leading to a notable increase in glutamine uptake [130]

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