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The findings underscore the importance of setting clear expectations with patients early in treatment, including the possibility that more than one medication may be prescribed before a long-term approach is identified

In practice, donepezil, an acetylcholinesterase inhibitor, is commonly prescribed for patients with PD to manage cognitive impairment and memory loss and might be an adjuvant to A 2A R antagonists to alleviate side effects [49]

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