In addition to acting through the p38 pathway, GLP-1RAs also promote the increase of PKA levels via the cAMP-dependent pathway, which in turn prevents the phosphorylation of epidermal growth factor receptor (EGFR) and activator of transcription 3 (STAT3), resulting in the inactivation of the EGFR-STAT3 signaling pathway in tumor cells and subsequently downregulating several downstream effector genes such as myelocytomatosis oncogene (c-Myc), survivin, cyclin D1, Bcl-xl, and Bcl-2, thereby inducing apoptosis in tumor cells in a dose-dependent manner [70, 73]
Identifying risks early is essential, but the bigger challenge is finding strategies that address the root causes of obesity, not just its symptoms
Beyond this window, degradation products accumulate and purity decreases progressively
Complications often related to obesity, such as heart disease, liver disease, high cholesterol, diabetes, sleep apnea, and breathing problems, can also occur
Chemical and functional characterization of the main bioactive molecules contained in hulled Cannabis sativa L