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Multiple studies have shown that vitamin E levels are significantly reduced in cirrhotic patients and decline with worsening disease severity [44, 45]

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A study on patients with HCM revealed abnormal copper accumulation, and the use of the Cu2+ selective chelator tretinoin hydrochloride was found to slow or reverse disease progression in HCM (73)

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Data availability This manuscript does not contain original data References Akram NA, Shafiq F, Ashraf M

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Nature , 445(7124), 177182

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Silvagno F, Vernone A, Pescarmona GP, et al

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