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Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG

In a hemophilia dog model, there was evidence of AAV integration four years after being treated with canine factor VIII (cFVIII) in an AAV8/9 vector, however, there was no evidence of tumor formation within these dogs that had AAV integration [151]

Ulagesan S, Santhamoorthy M, Tuong Vy Phan T, Alagumalai K, Thirupathi K, Kim S-C, et al

10.1016/j.jneuroim.2010.06.017 J

Although continuous treatment of park 13 flies with L-DOPA reduced the inherent oxidative stress consistent with previous results, the flies still showed considerably higher levels of oxidative radicals (Fig