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At the genus level, Bifidobacterium, Lactobacillus, Clostridium , and Escherichia increased, whereas Prevotella, Akkermansia, and Roseburia decreased, indicating a shift toward pro-inflammatory and dysbiotic profiles (Tamanai-Shacoori et al

With activist investors bemoaning returns on R&D and M&A investment and the loss of about $17bn in revenues looming from exclusivity expiries in 20252030, the company has been culling its pipeline and looking externally for assets

In patients with baseline normal ammonia levels, the NIRS data of l-carnitine group (n = 31) at 8 weeks of treatment were significantly better than that of the control group (n = 25) (0.11 0.09 vs