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In the context of IGFBP biology, IGF-1 LR3s 1000-fold reduced IGFBP affinity means it is not sequestered by IGFBP-3 (the major circulating IGF-1 carrier, ~75% of circulating IGF-1 is IGFBP-3 bound) or IGFBP-2 (the predominant IGFBP in muscle interstitium)

doi: 10.1021/acsami.5c05089 33 YunJZhangYZhangHXiaoFWangYXuPet al

Both reactions in the Rapoport-Luebering shunt are catalyzed by one multifunctional protein: 2,3-BPG mutase (BPGM) (EC 5.4.2.4).81,153 The mutase activity of this enzyme converts the glycolytic intermediate 1,3-BPG to 2,3-BPG

For scientists and clinicians, its an excellent candidate for further study

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