adding metformin to semaglutide and Together Metformin and Semaglutide Together: Safety

Diarrhea The second most common side effect, affecting a higher percentage of participants at higher doses

-Other metabolic hormones (like ghrelin and glucagon) were also decreased -These changes were associated with increased inflammatory activity in immune cells (macrophages) Why this study matters: GLP-1 is not just a weight loss hormone. It also: -Plays a role in inflammation regulation - Interacts with the immune system -Influences metabolic balance Lower GLP-1 levels in the pelvic environment may contribute to: -Increased inflammation -Altered immune responses -Progression of endometriosis lesions (still being studied) Why this study matters: GLP-1 is not just a weight loss hormone. It also: -Plays a role in inflammation regulation - Interacts with the immune system -Influences metabolic balance Lower GLP-1 levels in the pelvic environment may contribute to: -Increased inflammation -Altered immune responses -Progression of endometriosis lesions (still being studied) Based on published research comparing women with endometriosis to control groups

Injection site reactions are uncommon but can include temporary redness, itching, or mild swelling

Measurement of Lp(a) may be considered in patients with very high cardiovascular risk and atherosclerotic cardiovascular disease, in patients with familial hypercholesterolaemia, and in pregnant women in prevention of pre-eclampsia or miscarriage, in recurrent pregnancy loss, or intrauterine growth restriction

Tang X, Shay NF