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In patients who underwent multiple rounds of therapy, the probability of response or remission decreased with subsequent treatments, with only 21% response (22/106) and 10% remission (11/106) by the fourth therapy option [18]

Wound healing: 4 to 8 weeks or until healed

Materials and methods Search strategy and study selection This meta-analysis was performed based on the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) guideline (Reference Moher, Liberati and Tetzlaff37)

This can be achieved in a slow cooker on low, a stockpot on the stove set to low, or a dutch oven in the oven at 180F

10.3233/CH-221395 183 LoprinziP