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Five subtypes are predominant in the gastrointestinal tract: calcitonin gene-related peptide 1 (Calca), GLP-1 receptor (GLP-1R), G protein-coupled receptor 65 (Gpr65), vasoactive intestinal peptide (Vip), and oxytocin receptor (Oxtr) (24)

In ALS, for instance, IGF-1 treatment lead to significant reductions in disease progression, increased muscle strength, improved respiratory functioning, and increased quality of life

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In another randomised controlled trial, there was an increased incidence of cholelithiasis in patients receiving once daily liraglutide 3mg compared with placebo (0.45% vs 0%) during the 12 months (2)

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