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Very little metabolic effect
1 China is one of the countries with the fastest aging rates in the world, and the proportion of people aged 60 and above is expected to reach 28% by 2040
Among 169,649 patients with MASLD, GLP-1 receptor agonist initiation was linked to significantly lower probability of incident cirrhosis [adjusted hazard ratio (aHR): 0.86, 95%CI: 0.80-0.93], hepatic decompensation (aHR: 0.77, 95%CI: 0.65-0.90), and hepatocellular carcinoma (HCC) (aHR: 0.79, 95%CI: 0.68-0.92) over a median follow-up of 3.5 years compared to non-users
This section delineates the dysregulation of MQC pathways in age-related neurological deterioration and neurodegenerative disorders, providing a mechanistic framework to decipher the pathogenic cascades driving mitochondrial dysfunction