This is likely due to greater weight loss seen in this trial, approximately 21% with 15 mg dosing, far exceeding the 14% weight loss observed in GLP-1 RA trials [14, 16, 19, 20, 23]
When fat disappears too fast, the skin may not have time to contract and reshape
Fecal microbiota transplantation is a popular approach FMT was successfully applied in animal models and restored the structure of the gut microbiota in mice (155)
Thankfully, they do so without draining your wallet
A meta-analysis also showed that weight loss, but not a reduced HbA1c level, was significantly and independently associated with BP reductions in GLP-1RA and SGLT2 inhibitor treatment [4]