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However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18

The sacrifice was at day 3, 5, 7, and 14

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Crucially, Lorazepam rescued neuronal viability and suppressed ferroptosis in spinal I/R rats, effects fully negated by the GPR68 antagonist Ogremorphin (OGM)