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Additionally, obesity and excess adipose tissue can induce an inflammatory response, resulting in the production of a plethora of inflammatory mediators such as TNF-, IL-6, and CRP (van Kruijsdijk et al., 2009)

TRPV1 is also activated by capsaicin (hot peppers), low extracellular pH, and noxious heat.[ref] TRPA1 is activated by VOCs, cigarette smoke, heavy metals, naphthalene (moth balls), formaldehyde, and styrene.[ref] TRP receptors are highly expressed in the olfactory and trigeminal nerve endings and in the brain

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