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Fish Physiol Biochem 46:22432256 Xiao LD, Mai KS, Ai QH, Xu W, Wang XJ, Zhang WB, Liufu ZG (2010) Dietary ascorbic acid requirement of cobia ( Rachycentron canadum Linneaus)

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Key genetic variants include GLP1R rs6923761 (affecting GLP-1 pathway sensitivity), GIPR rs1800437 (glucose-dependent insulinotropic peptide response), FTO rs9939609 (metabolic flexibility), and MC4R rs17782313 (appetite regulation)

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This pharmacokinetic limitation contributed to the selection of subcutaneous injection for the approved Vyleesi product (reported in studies) [3] [10]

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