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Outcomes remain highly uncertain and hinge on uptake, effectiveness, persistency, and any benefits beyond BMI reduction so insurers should monitor this fast-moving landscape and consider implications for trend assumptions, lapse/anti-selection risk, underwriting, and claims

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December 15, 2025: Ozempic Blindness MDL Is Created for Patients Who Suffered Eye Stroke After Taking GLP-1s Patients diagnosed with non-arteritic anterior ischemic optic neuropathy (NAION) after taking Ozempic, other GLP-1s, can file a lawsuit in the new MDL created for these cases

"GLP-1 medications like Ozempic and Wegovy directly alter appetite signaling, gastric emptying and insulin secretion, producing large, predictable effects on weight and blood sugar," Perez explains