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NAC is the source of the sulfhydryl group that is essential for removing free radicals like H 2 O 2 , OH* and O 2 -*(Reference Sadowska, Manuel and De Backer47)

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In contrast, mitochondrial PRDX3 undergoes hyperoxidation during lipid peroxidation stress and translocates to the plasma membrane, where it suppresses cystine uptake, depletes intracellular GSH, and amplifies ferroptotic execution 114