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Peripheral neuropathy refers to the degeneration of nerves that mainly supply the muscles of the arms, hands, legs, and feet

doi: 10.1016/j.mucimm.2023.05.005 54 WangHLianPNiuXZhaoLMuXFengBet al

This reduces the levels of glucose and glycated hemoglobin in the plasma of T2DM patients [151], resulting in decreased insulin levels and increased glucagon release, thereby promoting the production of ketones [152]

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However, significant safety concerns and lack of regulatory approval limit their clinical utility