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Human plasma and tissue alpha-Tocopherol concentrations in response to supplementation with Deuterated natural and synthetic vitamin E

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This design enables three distinct pharmacological actions in a single molecule: GLP-1 receptor agonism : The two conjugated GLP-1 analog peptides activate GLP-1R to produce appetite suppression, glucose-dependent insulin secretion, glucagon suppression, and delayed gastric emptying GIP receptor antagonism : The antibody component blocks GIP signaling, which may reduce fat storage and modify energy metabolism Extended half-life : The antibody backbone provides a half-life of approximately 21 days -- three times longer than any approved weekly incretin therapy -- enabling once-monthly dosing The GIP antagonism approach is the most distinctive feature