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How Probiotics Combat Candida Probiotics can help treat Candida by: Preventing the formation of hyphae (long threads that branch off Candida, helping them colonize and cause infections) Crowding out Candida Keeping Candida from building biofilms Preventing Candida from sticking to the gut lining A meta-analysis (highest-quality study of studies) found that a combination of probiotics (a Lactobacillus / Bifidobacterium blend and various Saccharomyces species ) reduced oral Candida counts in people with oral thrush 13