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Many factors contribute to impaired adipogenesis including obesity-associated mild chronic inflammation, oxidative stress, and fatty acid signaling

Gastrointestinal Disorders: Conditions like Crohns disease or celiac disease can interfere with B12 absorption

Acid-reducing medications Medications commonly prescribed for heartburn, GERD, acid reflux and peptic ulcers, such as proton pump inhibitors like Prilosec, Prevacid and Nexium, or H2 (histamine2) receptor antagonists like Pepcid and Zantac, suppress the secretion of stomach acids, also blocking the secretion of intrinsic factor

600610., doi:10.1002/acr.20140

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