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Nutr Metab (2011) 8:34.10.1186/1743-7075-8-34 109 NareuseHHayashTITakesadaMNakaneAYamazakiKNoguchiTet alTherapeutic effect of tetrahydrobiopterin in infantile autism

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Possible changes in plasma levels of hepatically metabolized drugs Need for monitoring when used with narrow therapeutic index agents Concomitant administration with antioxidants and vitamin supplements is generally well tolerated, though excessive antioxidant load may blunt physiological redox signaling

A recent study showed that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in MCI patients [39]

Glutathione supports both Phase I and Phase II liver detoxification, with GSH conjugation constituting a major elimination pathway for drugs, metabolic waste products, and environmental toxins